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The phosphorylated HER3 gives docking internet sites for p85 subunit of PI3K. The absolutely activated PI3K complex is generated by binding of p110 subunit of PI3K to p85 which has the capacity to generate PIP3 through phosphorylating the PIP2. AKT binds to PIP3 and is also phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at equally threon